Hydrogen Medical Research

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What is Hydrogen?

Hydrogen gas has been acknowledged to have its effect on over 150 different diseases.

About Hydrogen

Hydrogen is the lightest atom, number 1 on the periodic table. It is composed of 1 electron and 1 proton. At a normal setting, it exists as a molecular hydrogen (H2).
Hydrogen is the key element for explaining the formation of this universe and the birth of all living species.

Molecular structure of Hydrogen: Hydrogen atom

Hydrogen atom (H) is neutral and has a electron not paired. Since this is a reactive free radical, it is quite rare
to find hydrogen atom at its state. When the hydrogen atoms are generated through electrolyte method, this hydrogen
atom easily reacts with the another hydrogen atom to form a molecular hydrogen (natural hydrogen gas state).

In 1990s, scientists claimed that hydrogen atoms have a treatment effect in Japan; however, such “reactive hydrogen atom”
had been mistranslated to “reactive hydrogen species” to English. “reactive hydrogen species” is not a scientific
term and this has been used in the exaggerated marketing advertisements.

At physical chemistry point-of-view, it is impossible to have a stable hydrogen atom.

Molecular structure of Hydrogen: Hydrogen molecule

When we typically say, hydrogen, we refer it to the hydrogen gas (H2). At this state, two hydrogen
atoms are bonded, so it is also known as diatomic hydrogen.

Molecular hydrogen has two protons and two electrons, so it is neutral. It is colorless, tasteless, odorless,
non-metallic, highly flammable gas.

So, when we refer to the hydrogen that has a treatment effect at a broad spectrum,
we are referring to this molecular hydrogen.

There’s no hydrogen in the “hydrogen water”.

In the past 10 years, “hydrogen water making machines” have been popular
in the market and these products are still being sold; however, there’s merely
no hydrogen in the “hydrogen water.”

Several years ago, broadcast news press had published that there’s no or very
small amount of hydrogen in the “hydrogen water” and even if it exists,
the hydrogen when exposed to the air would disappear into the atmosphere not allowing
it to be absorbed into the body, so drinking “hydrogen water” the same
as drinking regular water based on the press release announcement
by the Korean National Ministry of Food and Drug Safety. In scientific terms,
hydrogen gas does not naturally dissolve into the water.

The companies that make these kind of devices market their devices by saying that
the hydrogen concentration level is at 1,000 ppb maximum. However, this value,
while seems a lot, ppb is 1/1,000,000,000, so it is saying that there’s
only 1mg (0.001g) of hydrogen gas in the 1L of water.

New method of treating diseases: Hydrogen inhalation Research studies

New Method of treating diseases: hydrogen inhalation clinical trials

1 . Tai hyoung Cho 2 . Lee youn sung
1 . Korea University Anam Hospital Professor Dept.of Neurosurgery M.D.,Ph.D
2 . Hue Light Immunophysiology Institute

Hue Light Research center has searched and reviewed researches, clinical trials and articles related to hydrogen inhalation treatment worldwide at its vast scale over the last three years.
This article analyzed the effect of hydrogen inhalation treatment on each different diseases and has a purpose of providing the basics of the hydrogen inhalation treatment mechanism for further investigation.

Molecular hydrogen inhalation therapy has been acknowledged to show strong antioxidative and anti-inflammatory effect on the body in numerous clinical studies from 2007, and recently, hydrogen inhalation therapy is being recommended to be applied for treating pneumonia caused from COVID virus. Throughout the years, the clinical studies have shown that hydrogen inhalation can protect the lungs and other organs on patients with COVID-caused pneumonia. Meanwhile, the mechanism of this reaction of the molecular hydrogen for such outcome has not yet been discovered. However, many numerous studies suggest that molecular hydrogen can activate antioxidative and anti-inflammatory functions, ATP synthesis in the mitochondria, endoplasmic reticulum stress, and control apoptosis, autophagy, pyroptotic, ferroptosis and circadian rhythm. Furthermore, further research would be necessary to investigate on the mechanism of its function as it has a treatment potential on wide-range diseases.

This study analyzes the basic studies and recent clinical researches on hydrogen inhalation therapy to investigate the basic mechanism on how hydrogen reacts in the body.

Molecular hydrogen (H2) science

There has been over 1,200 studies related to hydrogen research up to Dec 2021; however, the hydrogen research is yet at its beginning level.

Because there’s still the need to investigate on how hydrogen reacts inside the body, the most efficient method to inhale hydrogen, the optimal concentration and frequency for treating different diseases. Up to this point, the studies have proven that hydrogen is effective for preventing and treatment the diseases.

Hue Light would continue to cooperate with the scientists and research departments to further conduct clinical researches.

Molecular hydrogen (H2) treatment mechanism

Hydrogen treatment research had been more focused on the effect of hydrogen, so the research on investigating the basic mechanism of how hydrogen works at the cellular level is yet to be discovered. However, as a result, the effect of hydrogen is surprisingly very outstanding in a wide level.

The frequently asked question when we talk about hydrogen medical is
“what is the evidence behind how hydrogen can treat the diseases?”
Up to now, generally, the researchers talk about how hydrogen can neutralize the excessive reactive oxygen species (ROS) and act as selective antioxidative agent” as an evidence.

However, when we explain about “selective” and how it reacts with ROS, the researchers cannot explain about how it reacts at the cellular level, this answer has its limitation on clearly explaining its mechanism.

How hydrogen enters into the cell and what it does inside the cell and how it reacts with the signaling functions and other elements have to be determined.
Therefore, for the future research, we must contribute to determining these factors in the research.

It is very reasonable to question the current medical research.

Many researchers have skeptical perspective about hydrogen medical and this is normal because hydrogen medical research is relatively weak. Up to today, hydrogen medical has been discovered for only 14 years (2007). The collected data up to this point is based on its effectiveness. Generally, in science, it takes a lot of years and practices to collect massive data, so it cannot happen in just a day.

Comparatively, how living cells acknowledge the oxygen – oxygen availability - has been discovered in 2001, which was after a long years of research about 300 years. So, the contributors in this discovery, William G. Kaelin Jr., Peter J. Ratcliffe, and Gregg L. Semenza received a Novel Prize in physiology or medicine in 2019. So, we must keep in mind that hydrogen had only been researched for 14 years.

The effect of Molecular hydrogen (H2)

The effect of hydrogen inside the body is very difficult to understand.

The effect is very broad in its spectrum.

There are over 1,200 research publications addressing the correlation between hydrogen and over 200 different diseases. So, hydrogen became like a “miracle treatment, treatment for all diseases,” so there had been so many different form of hydrogen introduced in the market without any medical evidence, mainly hydrogen water, drinking hydrogen water, hydrogen steamer, hydrogen bathing. However, the results of hydrogen inhalation therapy is phenomenal. We have seen advanced treatment effect of hydrogen inhalation on other chronic diseases that not yet had been studied in a deeper level.

From the western medical perspective, it seems to be difficult to justify hydrogen as we deeply observe and research it. Dr. Nanshan Zhong stated that “hydrogen treats the cause.” Hydrogen inhalation may act on the part of the body or whole body, so it has not yet been simplified. When we experience it on the healthy mice group, they made the rat to suffer from diabetes, hepatocirrhosis and stroke. After inhaling hydrogen, theses diseases have gotten better but the degree differed.

After investigating the research (2-hours of hydrogen inhalation conducted), the function of hydrogen is shown to be very broad as the results differed on different diseases. It is important to separate the symptoms to investigate how hydrogen reacts on which type of diseases first.

Then, it would be crucial to collect a big data on the experiences of massive people. Meanwhile, we should be careful when understanding the effect of hydrogen inhalation even when hydrogen inhalation is reported to be effective on certain diseases. Many of the researches conducted are based on an animal study and recently, there are clinical trials on real patients but there are not many yet. Furthermore, it is very important to consider that the statistics of the research study may not be equivalent with the clinical effect. For example, in the hydrogen research study that used the cell culture, they were able to discover that when the cells are exposed to hydrogen, the cell’s survival rate have increased. However, this does not have any relation as to how hydrogen would suppress the tumor cells. Professor Sun Xuejun had mentioned that “hydrogen acts as a balancer,” meaning that it works hard to revert back abnormal cells (including tumor cells) to normal cell.

These issues may differ on the application of cell culture as it cannot clearly demonstrate
the cell’s complex functionality inside the body.

We would have to pay close attention that treating a disease has to be looked at all levels of the whole-body. Therefore, the explanation that hydrogen acts to remove toxic free radicals would be too weak to conclude hydrogen’s functions.
If so, how would hydrogen be able to know if the cell is normal or abnormal? Professor Sun, Xuejun’s explanation about how hydrogen acts as a balancer at a cellular level claim that hydrogen is able to determine it because it is part of the genesis of life. Hydrogen has stored the genetic memory in our cells, so the cells automatically react when hydrogen enters. In this process, hydrogen orders the cells to grow normally. When the tumor cells have lost the functions and memory of the normal cells, hydrogen enters and helps these tumor cells to restore the lost memory.
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