Neurological diseases including Parkinson’s
Neurological diseases including Parkinson’s
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01
Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
Fujita, K., Nakabeppu, Y., & Noda, M. (2011).
It is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.
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02
Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease
Hirayama, M., Ito, M., Minato, T., Yoritaka, A., LeBaron, T. W., & Ohno, K. (2019).
A randomized, double-blinded, placebo-controlled, crossover trial of inhalation of ~1.2–1.4% hydrogen-air mixture or placebo for 10 minutes twice a day for 4 weeks in 20 PD patients revealed that OSIT-J (P = 0.77), UPDSR1 (P = 0.84), and UPDRS2 (P = 0.15) were not changed by hydrogen gas.
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03
Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia–reperfusion injury in rats – A possible new hydrogen resource for clinical use
Jin Cui, Xiao Chen, Xiao Zhai, Dongchen Shi, Rongjia Zhang, Xin Zhi, Xiaoqun Li, Zhengrong Gu, Liehu Cao, Weizong Weng, Jun Zhang, Liping Wang, Xuejun Sun, Fang Ji, Jiong Hou, Jiacan Su. (2016).
Water electrolysis-derived hydrogen inhalation had neuroprotective effects on cerebral ischemia/reperfusion injury in rats with the effect of suppressing oxidative stress and inflammation, and it is a possible new hydrogen resource to electrolyze water at the bedside clinically.
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04
Hydrogen inhalation ameliorated mast cell mediated brain injury after ICH in mice
Manaenko, A., Lekic, T., Ma, Q., Zhang, J. H., & Tang, J. (2013).
Hydrogen therapy is easy to use and proven to be neuroprotective. So far, there have been no reported side effects from the therapy. Further studies translating presented results into the clinical setting for ICH management are needed.
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05
Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial
Tamura, T., Hayashida, K., Sano, M. et al. (2017).
The first multicenter randomized trial is underway to confirm the efficacy of HI on neurological outcomes in comatose out-of-hospital cardiac arrest survivors. Our study has the potential to address HI as an appealing and innovative therapeutic strategy for PCAS in combination with TTM.
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06
Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats
Ting-Ting Li, Wan-Chao Yang, Yue-Zhen Wang, Tian Sun, Hong-Ling Cao, Jian-Feng Chen, Wen-Zhi Li. (2020).
These results showed that the inhalation of 42% H2 can alleviate nerve damage and improve neurological function after TBI in diabetic rats. Therefore, the inhalation of a high concentration of H2 may be associated with the treatment of traumatic brain injuries.
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07
Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats
Takeuchi, S., Nagatani, K., Otani, N., Nawashiro, H., Sugawara, T., Wada, K., & Mori, K. (2015).
The present study suggests that ingestion of HRW can improve neurological function outcome in the SHRSP model. This beneficial effect may be due to attenuation of BBB disruption via reduction in reactive oxygen species and suppression of MMP-9 activity in the hippocampus.
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08
Medical gases for stroke therapy: summary of progress 2015–2016
Huang, J. L., Zhao, B. L., Manaenko, A., Liu, F., Sun, X. J., & Hu, Q. (2017).
Medical gases have distinct advantages over pharmaceutical drugs such as the ease of diffusibility across the BBB and the mechanism of action may be via multiple pathways.
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09
Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H. (2017).
H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas.
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10
Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis
Murakami Y, Ito M, Ohsawa I. (2017).
Pretreatment with H2 suppressed H2O2-induced cell death, whereas post-treatment did not. Increases in the expression of anti-oxidative enzymes underlying the Nrf2 pathway in H2-treated cells indicated that mild stress caused by H2 induced increased resistance to exacerbated oxidative stress.
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11
Hydrogen therapy: from mechanism to cerebral diseases
Liu, C. L., Zhang, K., & Chen, G. (2016).
A systematic introduction of H2 therapy with regards to mechanisms and cerebral diseases both in animal and human subjects can make it easier to comprehend H2 therapy and therefore provide the basis for further clinical strategy.
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