Cancer
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01
Hydrogen gas inhibits lung cancer progression through targeting SMC3
Wang D, Wang L, Zhang Y, Zhao Y, Chen G. (2018).
All data suggested that H2 inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer.
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02
Hydrogen Gas in Cancer Treatment
Li, S., Liao, R., Sheng, X., Luo, X., Zhang, X., Wen, X., Zhou, J., & Peng, K. (2019).
The application of hydrogen gas in cancer treatment is still in its nascent stage, further mechanistic study and the development of portable instruments are warranted.
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03
Therapeutic potential of molecular hydrogen in ovarian cancer
Lei Shang, Fei Xie, Jiala Li, Yating Zhang, Mengyu Liu, Pengxiang Zhao, Xuemei Ma, Tyler W. Lebaron. (2018).
Molecular hydrogen may exert anti-tumor role in ovarian cancer through suppressing the proliferation of CSCs-like cells and angiogenesis.
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04
Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms
Luc Rochette, Marianne Zeller, Yves Cottin, Catherine Vergely. (2021).
Proton beam radiotherapy (PBT) offers great promise for the treatment of a wide variety of cancers due to the sharp decrease in the dose of radiation at a defined point. In these conditions, H2 and different types of H2 donors may represent a novel therapeutic strategy in cancer treatment.
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05
Hydrogen Gas in Cancer Treatment
Li, S., Liao, R., Sheng, X., Luo, X., Zhang, X., Wen, X., Zhou, J., & Peng, K. (2019).
The application of hydrogen gas in cancer treatment is still in its nascent stage, further mechanistic study and the development of portable instruments are warranted.
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06
Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case Report
Chen JB, Pan ZB, Du DM, Qian W, Ma YY, Mu F, Xu KC. (2019)
Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life.
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07
Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species
Ye Yang, Yaping Zhu, and Xiaowei Xi (2018)
Treatment with H2 may involve correction of the oxidative/anti-oxidative imbalance and suppression of inflammatory mediators.
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08
Hydrogen as a New Class of Radioprotective Agent
Ye Yang, Yaping Zhu, and Xiaowei Xi (2018)
These encouraging results suggested that H2 represents a potentially novel preventative strategy for radiation-induced oxidative injuries.
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09
Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications
Shigeo Ohta (2011)
H2 shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. H2 regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H2 remain elusive.
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10
Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients
Junji Akagi (2018)
The results suggest that hydrogen gas improves the prognosis of cancer patients by reducing the proportion of terminal PD-1+ CD8+ T cells.
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11
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, Ken-Ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh, Shigeo Ohta (2007)
The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.
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12
Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression
Shin-ichi Hirano, Haru Yamamoto, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, and Fumitake Satoh (2021)
H2 has shown excellent efficacy and safety as an antitumor agent and its clinical application may provide a new therapeutic strategy against cancer.
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13
Hydrogen Protects Mice from Radiation Induced Thymic Lymphoma in BALB/c Mice
Zhao, L., Zhou, C., Zhang, J., Gao, F., Li, B., Chuai, Y., Liu, C., & Cai, J. (2011).
The results show that H2 protects mice from radiation induced thymic lymphoma in BALB/c mice.
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