Although medical hydrogen gas has special effects on respiratory tract infection, this is a study of H2’s impact on allergic rhinitis (AR). All parameters of the experiment significantly reduced after HRS treatment (p<0.05). In conclusion hydrogen gas has an anti-inflammatory function on AR, and reduces the expression of IL-4 and IL-13. (Tongji University Hospital, Shanghai, China, Feb 16th, 2017)
Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. There is a new treatment for neuropathic pain. When water containing saturated level of hydrogen was ingested, allodynia and hyperalgesia were alleviated. (National Defense Medical College, Department of Ophthalmology, June 18th, 2014)
Molecular hydrogen (H2) appeared as an experimental agent in biomedicine approximately 40 years ago, yet the past 5 years seem to confirm its medicinal value in the clinical environment. H2 improves clinical end-points and surrogate markers in several clinical trials, from metabolic diseases to chronic systemic inflammatory disorders to cancer. (Department of Biomedical Sciences in Sport, Belgrade school of medicine, Serbia, May 4th 2015)
In recent years, it has become evident that molecular hydrogen is a particularly effective treatment for various disease experiments. As a result, hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Thus, hydrogen’s effectiveness is thus multifaceted. (Department of Dental Science, Okayama University Graduate School, Japan, September 14th, 2017)
H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species. Owing to its great efficacy and lack of adverse effects, H2 has promising potential for clinical use against many diseases. (Department of Biochemistry and Cell Biology, Institute of Development and Aging sciences, Graduate School of Medicine, Kosugi-machi, April 24th, 2014)
Scavenging and cleaning out of free radicals may act preventively or therapeutically. A number of substances that preferentially react with free radicals can serve as scavengers, thus increasing the internal capacity/activity of endogenous antioxidants and protecting cells and tissues against oxidative damage. (Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia, September 19th, 2016)
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. (Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Japan, June 8th, 2012)
Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. H2 also prevents chronic neurodegenerative diseases including Parkinson’s disease. (Tokyo Metropolitan Institute of Gerontology, Japan, May 3rd, 2017)
Hyperbaric oxygen (HBO) therapy is useful for varieties of clinical conditions, especially hypoxic-ischemic diseases. However, because of generation of reactive oxygen species (ROS), breathing oxygen gas at high pressures can cause oxygen toxicity in the central nervous system, leading to multiple neurological dysfunction, which limits the use of HBO therapy. Studies have shown that Hydrogen gas (H2) can diminish oxidative stress and effectively reduce active ROS associated with diseases.
Mortality of hemorrhagic shock is due to when aggressive treatment is applied to the patients. H2 gas inhalation delays the progression to irreversible shock. (School of Medicine, Keio University, Tokyo, Japan, September 2017)
The inability to successfully adapt to stress produces pathological changes that can lead to depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities and neuroprotective effects. (Heibei University School of Medicine, August 29th, 2017)
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it can act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. It was shown that hydrogen has anti-oxidative, anti-apoptotic, and anti-inflammatory effects that protects the cells.
Hyperglycemia is one of the major factors for hemorrhagic transformation after ischemic stroke. In this study, hydrogen gas reduced brain infarction, hemorrhagic transformation, and improved neurological function. (Department of Physiology and Pharmacology, Loma Linda University, CA, USA, April 25th, 2010)
Hydrogen is a colorless, odorless, tasteless and flammable gas. Hydrogen is considered a physiologically inert gas and is often used in deep sea diving medicine. In mammals, endogenous hydrogen is produced as a result of the fermentation of non-digestible carbohydrates by intestinal bacteria and it is absorbed into the systemic circulation. Recent evidence indicates that hydrogen is a potent anti-oxidative, anti-apoptotic and anti-inflammatory agent and so may have potential medical application.
Crohn's disease and ulcerative colitis, known together as inflammatory bowel diseases (IBDs), and celiac disease are the most common disorders affecting not only adults but also children. Both IBDs and celiac disease are associated with oxidative stress, and hydrogen gas can play a pivotal role about this. (Prešov University, Slovak Republic, Department of Ecology, Faculty of Humanities and Natural Sciences, 2016 July 29th) it protects neuroblast SH-SY5Y from apoptosis.