Parkinson’s is a nerve disease that is caused by the lack of dopamine in the brain. Major symptoms include shaking of hands and feet, slower movement, muscle stiffness and it might also develop dementia as complication. Symptoms arise the most around the age after 40s~50s, and it is categorized as an incurable disease.
Researches have been happening in Japan and USA to study whether molecular hydrogen, a strong anti-oxidant, has the ability to supress progression of Parkinson’s and other brain diseases.
This page organizes some important research papers on the relationship of hydrogen and Parkinson’s/brain diseases. (Source: https://www.ncbi.nlm.nih.gov) We hope that it will help Parkinson’s/brain disease patients and their families.
Hydrogen gas decreased oxidative stress (8-OHdG, 4-HNE and nitrotyrosine) and exerted neuroprotective effects (improvement of neurological score and reduction in infarct and hemorrhagic volumes) and also reduced MMP-9 activation in a middle cerebral artery occlusion model.
Stroke is a cerebrovascular disease with high mortality and morbidity. Despite extensive research, there are only a very limited number of therapeutic approaches suitable for treatment of stroke patients as yet. Mounting evidence has demonstrated that such gases as oxygen, hydrogen and hydrogen sulfide are able to provide neuroprotection after stroke. (Discipline of Neuroscience, Department of Anatomy, Shanghai Jia Tong University School of Medicine Jun 30th, 2017)
Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. The H2 group showed no significant adverse effects with improvements in oxygen saturation. H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas. (Department of Neurosurgery, Nishijima Hospital, Numazu-city, Shizuoka-ken, Japan Jun 29th, 2017)
Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. It prevents chronic neurodegenerative diseases including Parkinson's disease in animal and clinical studies. (Tokyo Metropolitan Institute of Gerontology, May 3rd, 2017)
Brain disease is introduced due to damage of brain tissues and cell damage, which is basically induced by oxidative stress. Neurodegenerative diseases are divided into two types: one impacting movement, such as cerebellar ataxia, and the other affecting memory and is related to dementia. Study found that inhaling molecular hydrogen deter the decline of memory and learning ability. (Department of Neurosurgery & Brain and nerve Research Laboratory, the first affiliated hospital of Soochow university, Suzhou, Jiangsu Province, China)