Clinical studies on brain fatigue

Clinical studies on brain fatigue
  • Hydrogen inhalation stimulates cerebrum

    December 2016, from the result of Dr. Yada Yukihiro’s (University of Tsukuba) study on “autonomic nervous system” brain stress “validity assessment on the alteration of blood flow in frontal lobe” (17 female participants, in their 20s and 30s, had inhaled hydrogen, and the results were validated through integral psychophysiological evaluation system) show innovative outcomes. From the brain blood flow change detected through FMRI and tests from NIRS (national institute of radiological sciences), the frontal lobe was stimulated through hydrogen inhalation and the body had changed into a state of “peaceful body and mind that is able to concentrate efficiently”. Dr. Yada suggests that hydrogen inhalation has a tremendous effect compared to the pre-existing hydrogen water ingestion method.

  • Summary of objective data showing that hydrogen inhalation decreases brain fatigue

    (the following is a part of Dr. Yada’s research paper, from University of Tsukuba Graduate studies)

  • Increased temperature of the finger tips due to hydrogen inhalation

    When sympathetic nerve is activated, blood doesn’t flow as well to finger tips and toes because blood is usually concentrated in major muscles, heart, and eyes. This is the reason why the heart races, digestion is troubled, and stomach/hand/feet get cold when the body tenses up. Through measuring the fingertip temperature, Dr. Yada confirmed that skin temperature increased about 3℃ after hydrogen inhalation. Fingertip/toe temperature is a major barometer that indicates the degree of tension and relaxation (degree of sympathetic nerve activation), and it proved that molecular hydrogen inhalation is a way to suppress sympathetic nerve and activating parasympathetic nerve quickly and safely.

    in this experiment, the subjects’ fingertip temperature increased by average of 3.4 ℃ and there was a case where the temperature increased up to 7 ℃.
    Dr. Yada tried multiple physiological experiments like sauna, thermotherapy, etc and stated that there was no experiment that increased body temperature in such a large range in such a short time.

  • Rate of Meiosis: Pupil constriction occurs as parasympathetic nerve is stimulated.

    When sympathetic nerve is activated, blood concentrates to the eyes. Dr. Yada studied pupil constriction rate of pre- and post- hydrogen inhalation.

    Change in meiosis rate after hydrogen inhalation

    This experiment assesses the state of autonomic nerve system through the dilation and constriction of a pupil, and strong constriction occurred after hydrogen inhalation (figure above).

    rom the experiments “change of fingertip temperature” and “measuring meiosis rate”, it is found that hydrogen inhalation plays a huge role in autonomic nerve system activity. Hence meaning that it is confirmed when hydrogen is inhaled, parasympathetic nerve system is stimulated. With a different perspective, it can be assumed that fingertip temperature raised not because of activated parasympathetic nerves, but because of suppressed sympathetic nerve and maintained balance of autonomic nerves.

  • Things that happen to the brain through hydrogen inhalation

    Psychological changes include declined stress/fatigue, and increased motivation and concentration.

    Therefore, molecular hydrogen inhalation applies to two sides (body and mind) and to find this mechanism, the reactivity or the function of the brain during hydrogen inhalation must be studied. To study and analyze the brain function, Dr. Yada uses NIRS (Near-infrared Spectroscopy), which have been drawing attention as the newest technology, and fMRI.

  • Molecular Hydrogen Inhalation activates frontal lobe

    NIRS is a device that observes the change of blood flow in brain, skin, muscle, etc, through radiating light source of near infrared ray with the 770nm~950nm. Through near infrared ray that is irradiated towards the body, the change of oxygen concentration in hemoglobin in the blood and brain activity can be observed.

    Cerebral blood flow of frontal cortex (forehead), where it controls emotion, cognition, memory, and behavior is studied.

    16 sensors were attached to compare the change in brain blood flow 5 minutes before and 5 minutes after the hydrogen inhalation.

    Comparing pre-/post- hydrogen inhalation, significant increased brain blood flow was observed around the center of frontal cortex after hydrogen inhalation (photo above). Increased brain blood flow through molecular hydrogen inhalation indicates activation of the brain.

    During work, during studying, and during everyday activities, the most effective method to activate brain within a short time is only “hydrogen inhalation”.

    Dr. Yada, who observed the increased blood flow at frontal cortex after hydrogen inhalation, analyzed the change in brain activity of 5 subjects pre-/post- hydrogen inhalation through fMRI. As a result, like the NIRS test results, increased blood flow around frontal cortex was observed.

    Dr. Yada demonstrated that hydrogen inhalation activates brain activity and also assured that more research is needed in diseases such as Parkinson’s and dementia.