Lung cancer is one of the most common lethal malignancies in the globe. The patients' prognoses are dim due to its high metastatic potential and drug resistance. In this research, during the search for lung cancer cure, it was discovered that molecular hydrogen (H2) has suppressed the lung cancer progression through the Structural Maintenance of Chromosomes 3 (SMC3). (Hebei Medical University, 2018 May 29th)
Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects in Acute Lung Injury (ALI) treatment. This study examined the effects of inhaled hydrogen on ALI caused by HS/R.
HS/R induced ALI, as demonstrated by significantly impaired gas exchange, congestion, edema, cellular infiltration, and hemorrhage in the lungs. Hydrogen inhalation mitigated lung injury after HS/R, as indicated by significantly improved gas exchange and reduced cellular infiltration and hemorrhage. Hydrogen inhalation did not affect hemodynamic status during HS/R. (Department of Emergency, Disaster and Critical Care Medicine, Hyogo College of Medicine, Nishinomiya, Japan, May 14th 2015)
Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that oxidative stress and endothelial cell death in vivo of ALI can be stopped. (University of Wisconsin Medical Center, Milwaukee, USA, Oct 1st 2017)
Hydrogen inhalation functions as an anti-oxidant and can be useful as a new therapeutic treatment gas. Inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and anti-apoptotic effects.
According to this study using rats, inhaling small amounts of hydrogen in addition to concentrated oxygen may help stem the damage the lung tissue that occurs when critically ill patients are given oxygen for long periods of time.